Enbrel is a prescription medicine used to treat the symptoms of ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis, plaque psoriasis, and juvenile rheumatoid arthritis. Enbrel may be used alone or with other medications.

Enbrel belongs to a class of drugs called Antisoriatics, Systemic, Immunosuppressants, DMARDs, TNF Inhibitors, Immunosuppressives, PHD.

Etanercept, a tumor necrosis factor (TNF) blocker, is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodaltons (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain, and the hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons.

Enbrel Info

Administration of one 50 mg Enbrel single-dose prefilled syringe, one single-dose prefilled Enbrel SureClick autoinjector, or one Enbrel Mini single-dose prefilled cartridge (for use with the AutoTouch reusable autoinjector only), provides a dose equivalent to two 25 mg Enbrel single-dose prefilled syringes, two 25 mg single-dose vials, or two multiple-dose vials of lyophilized Enbrel, when multiple-dose vials are reconstituted and administered as recommended.

Enbrel Side Effects

The most common side effects include: 

  • pain, swelling, itching, or redness at the injection site, and
  • cold symptoms (stuffy nose, sneezing, sore throat)


Patient Assistance Programs

There are several programs patients can sign up for that will assist in treatment costs:


To learn more about this treatment, browse the resources below.

Order Form

To download the order form for this treatment, click below.

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