Orencia is a prescription medicine used to treat the symptoms of Moderate-to-Severe Rheumatoid Arthritis and Psoriatic Arthritis. Orencia may be used alone or with other medications.

Orencia belongs to a class of drugs called DMARDs, Immunomodulators; Immunosuppressants.

ORENCIA® (abatacept) is a selective T cell costimulation modulator. ORENCIA is a soluble fusion protein that consists of the extracellular domain of human cytotoxic T-lymphocyteassociated antigen 4 (CTLA-4) linked to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Abatacept is produced by recombinant DNA technology in a mammalian cell expression system. The apparent molecular weight of abatacept is 92 kilodaltons.

Orencia Info

For adult patients with RA, administer as an intravenous infusion or as a subcutaneous injection. ORENCIA may be used as monotherapy or concomitantly with disease-modifying antirheumatic drugs (DMARDs) other than JAK inhibitors or bDMARDs (e.g., TNF antagonists).

Intravenous Dosing Regimen

Reconstitute ORENCIA lyophilized powder and administer after dilution [see DOSAGE AND ADMINISTRATION] as a 30-minute intravenous infusion utilizing the weight range-based dosing specified in Table 1. Following the initial intravenous infusion, administer as an intravenous infusion at 2 and 4 weeks and every 4 weeks thereafter.

Orencia Side Effects

The most common side effects include: 

  • fever,
  • nausea,
  • diarrhea,
  • stomach pain,
  • headache, and
  • cold symptoms (stuffy nose, sneezing, sore throat, cough)


Patient Assistance Programs

There are several programs patients can sign up for that will assist in treatment costs:


To learn more about this treatment, browse the resources below.

Order Form

To download the order form for this treatment, click below.

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